Solid Pharmaceutical Machines such as Blister Machines, Cartoning Machines and Liquid Pharmaceutical Machines
Solid Pharmaceuticals
Bosch is one of the leading suppliers of packaging technology: we provide far more than well-proven machines, we also deliver complete concepts that satisfy all requirements placed on modern technology - from ergonomic design right up to user friendliness. Our modularly structured machine concepts allow us to react quickly and flexibly to satisfy your individual requirements. Bosch takes over responsibility for whole packaging lines. This means you only ever have a single, reliable personal contact and can always count on genuine Bosch quality. SOLID PHARMACEUTICALS The strength of Bosch in the pharmaceutical solids field is based upon our nearly 40 years of experience. We work with innovative motive power engineering and satisfy international standards as a provider of complete lines. The modularly structured concept of our machines allows each of our packaging machines to be delivered quickly, easily installed world-wide without changeover and thus lets you flexibly relocate the installations from site to site. Bosch packaging technology can be optimally converted or upgraded so that all market requirements can be satisfied in the future. Find out about our integral inspection and weighing technology and our product protection process. BLISTERS When pharmaceutical products are packed in blister packs, Bosch relies on machines with a modular construction that makes them highly flexible and universally installable. All machines conform with pharmaceutical security requirements and can also be delivered quickly. Blister Machines Variofill- More Tolerance, Variability and Higher Speed The reliable and gentle feed of products with large tolerances and complex product shapes is the field of application of VARIOFILL. The new feed system for blister machines guarantees high flexibility and high efficiency. You can increase the efficiency of up to 100% with VARIOFILL compared with conventional infeed systems. In addition VARIOFILL opens up entirely new possibilities for the standardisation of blister and folding cartons. Variofill is available for following blister machines: - NT 25 - TLT 1400 Servac NT 25- Deployed with Great Flexibility and Versatility On account of its modular construction the Servac NT 25 can be deployed with great flexibility and versatility and meets your requirements of pharmaceutical security for the lower output range. A GMP-compliant design and short size changeover times makes the NT 25 ideal for small batch runs or contract packing. In addition to the excellent price-performance-ratio the short delivery time is another important argument for the economic attractiveness of the machine. TLT 1400 S- For Fast Product Changes The TLT 1400 S is a flexible, compact and versatile blister machine with a modern and modular construction as well as servo drives. Retrofitting of variants and optional extras are easily completed due to the intelligent machine design. Unrivalled small and light size tools for shortest size changeover times. Recommended Cartoning Machines: - CUT 120 S - CTK 2406, 3304, 4004 TLT 2800 S- Reduced Operating Errors The TLT 2800 S is a flexible, compact and versatile blister machine with servo drives and a modular construction. Integration of the Windows-NT user surface with its clear design simplifies operative machine handling and reduces operating errors. Recommended Cartoning Machines: - CTK 2406, 3304, 4004 FOLDING CARTONS The rule for the topic of folding cartons is: structured modular groups and machines with standardised interfaces are the guarantor for operational reliability and high availability. In this context, Bosch cartoning machines for folding cartons are impressive due to their ease of operation and size changeover as well as their maximum individuality for custom-tailored usage. Cartoning Machines CUT 120 The Bosch CUT 120 cartoning machine offers high flexibility due to the modular design of the machine equipment for combining different feed and sealing versions. The GMP-compliant machine design and clearly arranged, easily accessible production area ensure the results are the best possible. Recommended Bosch blister machines: - TLT 1400 CUC/CTC-Cartoning Machines The CUC/CTC-Cartoning machines have an excellent accessibility, highest pharmaceutical safety and a flexibility which up till now unachieved in this output range. The most important innovation is the fully servo driven product inserter. The awkward procedure of adjusting to new sizes, as it was known from former continuous motion cartoning machines, is a matter of the past. The carton transport system works without chains or belts and is completely maintenance free. The modular design of the machine enables retrofitting of options, e.g. different closure varieties or new infeed modules. Car T5 The Car T5 guarantees high flexibility due to the modular design of its machine equipment for combining different feed and sealing versions. Operational reliability is also guaranteed with different carton qualities. Its simple, fast, reproducible size changeover with easy handling and maintenance also make the CAR T5 impressive. Recommended Bosch blister machines: - TLT 1400 CTK S The CTK S high-performance cartoning machine with an output of up to 400 folding cartons per minute was designed to work inline with Bosch TLT thermoforming machines. The CTK S is outstanding due to its cartoning technology, integral IPC control system, operating panel with touch screen and its validatable technology. Recommended Bosch blister machines: - TLT 1400 S - TLT 2800 S CUK In addition to its many advantages such as high flexibility of ease of operation or high operational reliability the Bosch CUK is also outstanding because of its robust construction and low-wear operation. It guarantees dependable product feed, reliable feed and erection of folding cartons as well as fast and perfect size changeover. CUK 1060 and 1070 A The CUK 1060 and 1070 excel because of their low space requirements. They provide complete ampoule/vial packaging on one machine and high flexibility due to the modularly constructed machine equipment.
Bosch is one of the leading suppliers of packaging technology: we provide far more than well-proven machines, we also deliver complete concepts that satisfy all requirements placed on modern technology - from ergonomic design right up to user friendliness. Our modularly structured machine concepts allow us to react quickly and flexibly to satisfy your individual requirements. Bosch takes over responsibility for whole packaging lines. This means you only ever have a single, reliable personal contact and can always count on genuine Bosch quality.
The strength of Bosch in the pharmaceutical solids field is based upon our nearly 40 years of experience. We work with innovative motive power engineering and satisfy international standards as a provider of complete lines. The modularly structured concept of our machines allows each of our packaging machines to be delivered quickly, easily installed world-wide without changeover and thus lets you flexibly relocate the installations from site to site.
Bosch packaging technology can be optimally converted or upgraded so that all market requirements can be satisfied in the future. Find out about our integral inspection and weighing technology and our product protection process.
When pharmaceutical products are packed in blister packs, Bosch relies on machines with a modular construction that makes them highly flexible and universally installable. All machines conform with pharmaceutical security requirements and can also be delivered quickly.
Variofill- More Tolerance, Variability and Higher Speed
The reliable and gentle feed of products with large tolerances and complex product shapes is the field of application of VARIOFILL. The new feed system for blister machines guarantees high flexibility and high efficiency. You can increase the efficiency of up to 100% with VARIOFILL compared with conventional infeed systems. In addition VARIOFILL opens up entirely new possibilities for the standardisation of blister and folding cartons.
Variofill is available for following blister machines:
- NT 25 - TLT 1400
Servac NT 25- Deployed with Great Flexibility and Versatility
On account of its modular construction the Servac NT 25 can be deployed with great flexibility and versatility and meets your requirements of pharmaceutical security for the lower output range. A GMP-compliant design and short size changeover times makes the NT 25 ideal for small batch runs or contract packing. In addition to the excellent price-performance-ratio the short delivery time is another important argument for the economic attractiveness of the machine.
TLT 1400 S- For Fast Product Changes
The TLT 1400 S is a flexible, compact and versatile blister machine with a modern and modular construction as well as servo drives. Retrofitting of variants and optional extras are easily completed due to the intelligent machine design. Unrivalled small and light size tools for shortest size changeover times.
Recommended Cartoning Machines:
- CUT 120 S - CTK 2406, 3304, 4004
TLT 2800 S- Reduced Operating Errors
The TLT 2800 S is a flexible, compact and versatile blister machine with servo drives and a modular construction. Integration of the Windows-NT user surface with its clear design simplifies operative machine handling and reduces operating errors.
- CTK 2406, 3304, 4004
The rule for the topic of folding cartons is: structured modular groups and machines with standardised interfaces are the guarantor for operational reliability and high availability. In this context, Bosch cartoning machines for folding cartons are impressive due to their ease of operation and size changeover as well as their maximum individuality for custom-tailored usage.
CUT 120
The Bosch CUT 120 cartoning machine offers high flexibility due to the modular design of the machine equipment for combining different feed and sealing versions. The GMP-compliant machine design and clearly arranged, easily accessible production area ensure the results are the best possible.
Recommended Bosch blister machines:
- TLT 1400
CUC/CTC-Cartoning Machines
The CUC/CTC-Cartoning machines have an excellent accessibility, highest pharmaceutical safety and a flexibility which up till now unachieved in this output range. The most important innovation is the fully servo driven product inserter. The awkward procedure of adjusting to new sizes, as it was known from former continuous motion cartoning machines, is a matter of the past. The carton transport system works without chains or belts and is completely maintenance free. The modular design of the machine enables retrofitting of options, e.g. different closure varieties or new infeed modules.
Car T5
The Car T5 guarantees high flexibility due to the modular design of its machine equipment for combining different feed and sealing versions. Operational reliability is also guaranteed with different carton qualities. Its simple, fast, reproducible size changeover with easy handling and maintenance also make the CAR T5 impressive.
CTK S
The CTK S high-performance cartoning machine with an output of up to 400 folding cartons per minute was designed to work inline with Bosch TLT thermoforming machines. The CTK S is outstanding due to its cartoning technology, integral IPC control system, operating panel with touch screen and its validatable technology.
- TLT 1400 S - TLT 2800 S
CUK
In addition to its many advantages such as high flexibility of ease of operation or high operational reliability the Bosch CUK is also outstanding because of its robust construction and low-wear operation. It guarantees dependable product feed, reliable feed and erection of folding cartons as well as fast and perfect size changeover.
CUK 1060 and 1070 A
The CUK 1060 and 1070 excel because of their low space requirements. They provide complete ampoule/vial packaging on one machine and high flexibility due to the modularly constructed machine equipment.
Capsule and Antibiotic Filling and Sealing Machines
FOLDING CARTONS Inspection Machines- Checkweighers KWE Bosch electronic checkweighers in the extensive Bosch checkweigher module program are equipped with microprocessor control systems and are ideal for universal applications. Child Resistant Packaging Stora Enso Pharma SHR Stora Enso Pharma SHR - a child resistant, yet senior friendly and convenient compliance packaging for new, highly potent drugs. Meeting the highest European and US requirements and keeping complaint rates low is no longer a challenge. Pharma SHR has a unique opening mechanism, which is proven to be very easy to open for adults, yet inaccessible for children’s small hands. With the carton providing the full child resistance, the primary packaging inside needs no further child resistance. CAPSULES The filling process for capsules demands machines with a maximum amount of precision and pharmaceutical security. First class technology from Bosch fully satisfies these requirements. Precise function sequences and maximum economy are guaranteed by the filling and sealing machines. And that is with first class user convenience. Hard Gelatine Capsule Filling and Sealing Machines GKF-1400 The medium performance machine for the dependable and gentle dosing of powders, pellets, tablets and filling combinations. Controlled with industrial PC and, of course, with 21 CFR Part 11-compliant software. GKF 2500 ASB The high-performance machine for extremely high productivity in the filling of powders, pellets and tablets. Particularly suitable for difficult and sensitive products. Controlled by industrial PC and 21 CFR Part 11-compatible software. GKF 2500 ASB 100% The GKF 2500 ASB 100% is the only machine that is equipped with high-precision, gravimetric online capsule weighing. The machine has automatic readjustment to dosing parameters. Through PC control and extensive Window software the production process can be completely documented. In addition an extremely high level of machine availability is guaranteed by the automatic troubleshooting system (ASB). GKF 2500 ASB IPK Capsules are removed from the segments at preselectable intervals and weighed on the weigher as random samples. Any weight changes incurred are readjusted by the pneumatic tamping pin adjuster. Upon completion of production the entire production progression can be saved and printed out. GKF 2500 S Whatever products you may process - powders, pellets or tablets: the GKF 2500 S achieves unsurpassed precise dosing at a very high output and with extremely lowloss of powder. Controlled by industrial PC and 21 CFR Part 11-compatible software. GFK 700 S The GFK 700 S was developed for medium-scale and very flexible production requirements. The machine's optimum price/performance ratio is impressive. For this purpose, its exceedingly fast delivery times are guaranteed by its quick availability. GKF 701 A combination of powder, pellets and tablets can be filled into one capsule. Additionally, all GKF 700 size parts can be used. The machine is equipped with a Touchscreen and has a user-friendly operator panel. INFUSION BOTTLES When powder-type drugs are filled into infusion bottle it is vital to work with precision in sterile conditions. Therefore, Bosch offers lines that precisely meet customer needs. And deliver high reliability and economy when filling and sealing powder. Antibiotic Filling and Sealing Machines AFG The AFG doses sterile powders into injection vials and closes them with a rubber stopper, all under aseptic conditions. Due to the new machine concept with vertical machine plate, significant advantages are achieved particularly with a view to pharmaceutical security and process dependability. MACHINES BY DOSAGE FORM Powder/Granulates Precisely calibrated and exact dosing is needed for filling powders or granulate products. Our machines satisfy this task as fast as possible and in compliance with current pharmaceutical guidelines. And therefore no limits are placed upon economic production with maximum product quality. Tablets When tablets are packed and packaged it is important that the filled product is filled and packaged reliably and reproducibly with the minimum number of operating personnel. Our machines satisfy this task as fast as possible and in compliance with current pharmaceutical guidelines. And therefore guarantee maximum economy and quality for your production. Coated Tablets When coated tablets are filled into containers and packaged it is important that the product is filled and packaged reliably and reproducibly with the minimum number of operating personnel. Our machines satisfy this task as fast as possible and in compliance with current pharmaceutical guidelines. And therefore guarantee maximum economy and quality for your production. Capsules Dosing that is precisely calibrated and exact is vital when it comes to filling bulk wares into capsules. Care must be taken that large quantities of dust do not form. Our machines satisfy these requirements outstandingly. In addition to maximum pharmaceutical security, Bosch guarantees that its packaging machines deliver reliable and reproducible functional flows and therefore grant a maximum amount of economy to the filling and packing processes for your pharmaceutical products. Semi-Solid Drugs, Liquid Drugs, Aerosols and Plasters in Secondary Packaging Speed and diligence are the important factors when packaging semi-solid drugs such as ointments and salves, liquid drugs, aerosols and plasters. In addition to economy, Bosch packaging machines guarantee utmost flexibility in the size selection. Changes in the size range of the cardboard packages are uncomplicated and can be completed quickly. Therefore, our machines provide you and your production with optimum facilities to complete packaging rationally, quickly and reliably.
Inspection Machines- Checkweighers
KWE
Bosch electronic checkweighers in the extensive Bosch checkweigher module program are equipped with microprocessor control systems and are ideal for universal applications.
Child Resistant Packaging
Stora Enso Pharma SHR
Stora Enso Pharma SHR - a child resistant, yet senior friendly and convenient compliance packaging for new, highly potent drugs. Meeting the highest European and US requirements and keeping complaint rates low is no longer a challenge. Pharma SHR has a unique opening mechanism, which is proven to be very easy to open for adults, yet inaccessible for children’s small hands. With the carton providing the full child resistance, the primary packaging inside needs no further child resistance.
The filling process for capsules demands machines with a maximum amount of precision and pharmaceutical security. First class technology from Bosch fully satisfies these requirements. Precise function sequences and maximum economy are guaranteed by the filling and sealing machines. And that is with first class user convenience.
Hard Gelatine Capsule Filling and Sealing Machines
GKF-1400
The medium performance machine for the dependable and gentle dosing of powders, pellets, tablets and filling combinations. Controlled with industrial PC and, of course, with 21 CFR Part 11-compliant software. GKF 2500 ASB
The high-performance machine for extremely high productivity in the filling of powders, pellets and tablets. Particularly suitable for difficult and sensitive products. Controlled by industrial PC and 21 CFR Part 11-compatible software.
GKF 2500 ASB 100%
The GKF 2500 ASB 100% is the only machine that is equipped with high-precision, gravimetric online capsule weighing. The machine has automatic readjustment to dosing parameters. Through PC control and extensive Window software the production process can be completely documented. In addition an extremely high level of machine availability is guaranteed by the automatic troubleshooting system (ASB).
GKF 2500 ASB IPK
Capsules are removed from the segments at preselectable intervals and weighed on the weigher as random samples. Any weight changes incurred are readjusted by the pneumatic tamping pin adjuster. Upon completion of production the entire production progression can be saved and printed out.
GKF 2500 S
Whatever products you may process - powders, pellets or tablets: the GKF 2500 S achieves unsurpassed precise dosing at a very high output and with extremely lowloss of powder. Controlled by industrial PC and 21 CFR Part 11-compatible software.
GFK 700 S
The GFK 700 S was developed for medium-scale and very flexible production requirements. The machine's optimum price/performance ratio is impressive. For this purpose, its exceedingly fast delivery times are guaranteed by its quick availability.
GKF 701
A combination of powder, pellets and tablets can be filled into one capsule. Additionally, all GKF 700 size parts can be used. The machine is equipped with a Touchscreen and has a user-friendly operator panel.
When powder-type drugs are filled into infusion bottle it is vital to work with precision in sterile conditions. Therefore, Bosch offers lines that precisely meet customer needs. And deliver high reliability and economy when filling and sealing powder.
Antibiotic Filling and Sealing Machines
AFG
The AFG doses sterile powders into injection vials and closes them with a rubber stopper, all under aseptic conditions. Due to the new machine concept with vertical machine plate, significant advantages are achieved particularly with a view to pharmaceutical security and process dependability.
Powder/Granulates
Precisely calibrated and exact dosing is needed for filling powders or granulate products. Our machines satisfy this task as fast as possible and in compliance with current pharmaceutical guidelines. And therefore no limits are placed upon economic production with maximum product quality.
Tablets
When tablets are packed and packaged it is important that the filled product is filled and packaged reliably and reproducibly with the minimum number of operating personnel. Our machines satisfy this task as fast as possible and in compliance with current pharmaceutical guidelines. And therefore guarantee maximum economy and quality for your production.
Coated Tablets
When coated tablets are filled into containers and packaged it is important that the product is filled and packaged reliably and reproducibly with the minimum number of operating personnel. Our machines satisfy this task as fast as possible and in compliance with current pharmaceutical guidelines. And therefore guarantee maximum economy and quality for your production.
Capsules
Dosing that is precisely calibrated and exact is vital when it comes to filling bulk wares into capsules. Care must be taken that large quantities of dust do not form. Our machines satisfy these requirements outstandingly. In addition to maximum pharmaceutical security, Bosch guarantees that its packaging machines deliver reliable and reproducible functional flows and therefore grant a maximum amount of economy to the filling and packing processes for your pharmaceutical products.
Semi-Solid Drugs, Liquid Drugs, Aerosols and Plasters in Secondary Packaging
Speed and diligence are the important factors when packaging semi-solid drugs such as ointments and salves, liquid drugs, aerosols and plasters. In addition to economy, Bosch packaging machines guarantee utmost flexibility in the size selection. Changes in the size range of the cardboard packages are uncomplicated and can be completed quickly. Therefore, our machines provide you and your production with optimum facilities to complete packaging rationally, quickly and reliably.
Liquid Pharmaceutical Applications
We possess extraordinary pharmaceutical expertise with over 10,000 installations installed around the world for the pharmaceutical liquids sector and as the world leader in sterile applications. We deliver our machines and installations not only in compliance with the relevant international standards, but our documentation, qualification and validation can also help you to start production with your new installations much faster and much more easily. MACHINES Ampoules / Ampoules and Injection Bottles The manufacturing process for ampoules or combined processing of ampoules and injection bottles typically begins with a compact system. Ampoule compact systems are finished using sterile room equipment (on-site sterile room) or with the innovative isolator technology (machine sterile room). The containers are checked, labelled and end-packaged on subsequent machines. Bosch provides an individually configurable range of machinery for these applications for maximum production capacities of up to 27,000 ampoules per hour. Processing Steps Cleaning Sterilisation Filling and sealing Colour ring marking Subsequent Processing Steps Check for particle freedom and cosmetic defects Check ampoules for impermeability with the inspection machine KLD Application of a self-adhesive label with the labeling machine ERS End packing of ampoules in thermoformed blisters, folding boxes and/or cartons with cartoning machines. Injection and Infusion Bottles The manufacturing process for injection bottles typically begins with a compact system. This consists of a washing machine, a drying and sterilising tunnel, a filling and sealing machine, an overseal capping machine as well as a system for traying-off. Compact systems for injection bottles are finished using sterile room equipment (on-site sterile room) or in the innovative isolator technology (machine sterile room). The containers are checked, labelled and end-packaged on subsequent machines. Bosch provides an individually configurable range of machinery for this application for maximum production capacities of up to 36,000 containers per hour. Processing Steps Cleaning Sterilisation Filling and pressing in stoppers Oversealing Traying off Subsequent Processing Steps Check for particle freedom and cosmetic defects Check injection bottles for impermeability with the inspection machine KLD Application of a self-adhesive label with the labeling machine ERS End packing of containers in thermoformed blisters, folding boxes and/or cartons with cartoning machines Screw Neck Bottles The manufacturing process for these types of containers is carried out by a line that typically has the following elements: washing machines, drying and sterilising tunnel, fill and seal machine as well as traying machinery. The containers are checked, labelled and end-packaged on subsequent machines. The Bosch individually configurable range of machinery includes plants for maximum production capacities of up to 24,000 containers per hour. Processing Steps Cleaning Sterilisation Filling and pressing in stoppers Oversealing Traying off Subsequent Processing Steps: Check for particle freedom and cosmetic defects Check containers for impermeability with the inspection machine KLD Application of a self-adhesive label with the labeling machine ERS End packaging of containers into folding cartons with cartoning machines Cartridges The manufacturing process for cartridges bottles typically begins with a compact system. This consists of a washing machine, a drying and sterilising tunnel, a filling and sealing machine, an overseal capping machine as well as a system for traying-off the cartridges. Compact systems for cartridges are finished using sterile room equipment (on-site sterile room) or in the innovative isolator technology (machine sterile room).The containers are checked, labelled and end-packaged on subsequent machines. Bosch provides an individually configurable range of machinery for this application for maximum production capacities of up to 36,000 cartridges per hour. Processing Steps Cleaning Sterilisation Filling and pressing in stoppers Subsequent Processing Steps Check for particle freedom and cosmetic defects (also possible inline) Application of a self-adhesive label on the labeling machine ERS End packing of cartridges in thermoformed blisters, folding boxes and/or cartons with cartoning machines Syringes The manufacturing process for injection bottles typically begins with a syringe compact system. This consists of a washing machine, a drying and sterilising tunnel, a filling and sealing machine, an overseal capping machine as well as a system for placing the syringes in trays. These compact systems are finished using sterile room equipment (on-site sterile room) or with the innovative isolator technology (machine sterile room). Bosch provides an individually configurable range of machinery for this application for maximum production capacities of up to 18,000 syringes per hour. Processing Steps Removal from trays Cleaning Sterilisation Filling and assembling Insertion in trays Further Processing Inspection for particle freedom and cosmetic defects (also possible inline before insertion into trays) Application of a self-adhesive label with the labeling machine ERS Needle-Free Injections Bosch also offers and individually configurable range of machinery for processing needle-free injections.
We possess extraordinary pharmaceutical expertise with over 10,000 installations installed around the world for the pharmaceutical liquids sector and as the world leader in sterile applications. We deliver our machines and installations not only in compliance with the relevant international standards, but our documentation, qualification and validation can also help you to start production with your new installations much faster and much more easily.
MACHINES
The manufacturing process for ampoules or combined processing of ampoules and injection bottles typically begins with a compact system. Ampoule compact systems are finished using sterile room equipment (on-site sterile room) or with the innovative isolator technology (machine sterile room). The containers are checked, labelled and end-packaged on subsequent machines. Bosch provides an individually configurable range of machinery for these applications for maximum production capacities of up to 27,000 ampoules per hour.
Processing Steps
Subsequent Processing Steps
The manufacturing process for injection bottles typically begins with a compact system. This consists of a washing machine, a drying and sterilising tunnel, a filling and sealing machine, an overseal capping machine as well as a system for traying-off. Compact systems for injection bottles are finished using sterile room equipment (on-site sterile room) or in the innovative isolator technology (machine sterile room). The containers are checked, labelled and end-packaged on subsequent machines. Bosch provides an individually configurable range of machinery for this application for maximum production capacities of up to 36,000 containers per hour.
The manufacturing process for these types of containers is carried out by a line that typically has the following elements: washing machines, drying and sterilising tunnel, fill and seal machine as well as traying machinery. The containers are checked, labelled and end-packaged on subsequent machines. The Bosch individually configurable range of machinery includes plants for maximum production capacities of up to 24,000 containers per hour.
Subsequent Processing Steps:
The manufacturing process for cartridges bottles typically begins with a compact system. This consists of a washing machine, a drying and sterilising tunnel, a filling and sealing machine, an overseal capping machine as well as a system for traying-off the cartridges. Compact systems for cartridges are finished using sterile room equipment (on-site sterile room) or in the innovative isolator technology (machine sterile room).The containers are checked, labelled and end-packaged on subsequent machines. Bosch provides an individually configurable range of machinery for this application for maximum production capacities of up to 36,000 cartridges per hour.
The manufacturing process for injection bottles typically begins with a syringe compact system. This consists of a washing machine, a drying and sterilising tunnel, a filling and sealing machine, an overseal capping machine as well as a system for placing the syringes in trays. These compact systems are finished using sterile room equipment (on-site sterile room) or with the innovative isolator technology (machine sterile room). Bosch provides an individually configurable range of machinery for this application for maximum production capacities of up to 18,000 syringes per hour.
Further Processing
Bosch also offers and individually configurable range of machinery for processing needle-free injections.
Liquid Pharmaceutical Machines
Machines by Type We possess extraordinary pharmaceutical expertise with over 10,000 installations installed around the world for the pharmaceutical liquids sector and as the world leader in sterile applications. We deliver our machines not only in compliance with the relevant international standards, but our documentation, qualification and validation can also help you to start production with your new installations much faster and much more easily. Washing Machines On these machines, containers are fed individually and considerately through several stations: flooding, washing (with or without ultrasonic support), blowing out and transfer to a downstream sterilising tunnel. RQU and RQN The washing machines RQU and RQN are ideal for washing ampoules. The installations outstanding due to their optimum accessibility, for instance, and are very easy to operate. RQU DZ and RQN DZ The washing machines RQU DZ and RQN DZ are ideal for washing injection and infusion bottles. The installations operate with a maximum of 10 stations for inner washing and 5 stations for outer washing of containers. RRU and RRN The RRU and RRN washing machines are ideal for washing injection bottles, infusion bottles, ampoules, cartridges and syringes. They are outstanding due to their optimum accessibility, for instance, and are very easy to operate. Sterilising Tunnel HQL HQL installations are ideal for sterilisation and depyprogenation of injection bottles, infusion bottles, ampoules, cartridges and ready-to-use syringes. This model is impressive due to a short dwell time in the tunnel which is the result of the hot air laminar flow process with its high degree of efficiency. Filling and Sealing Machines for Ampoules Bosch relies upon modern technologies in filling and sealing machines for ampoules. Thus these installations use, for instance, time/pressure filling systems for charging and laser technology for sealing. ALF The ALF model is ideal for filling and sealing ampoules, burn-open ampoules or injection bottles (in the combination version). The narrow design (800 mm width) ensures that operation is optimum. The machine is prepared for delivery together with an Isolator. Filling and Sealing Machines for Injection, Infusion and Screw Neck Bottles When it comes to filling and sealing screw neck bottles the best solution is to use Bosch filling and sealing machines. Their outstanding features include, for instance, GMP-compliant design, slim construction and delivery for a wide output range, up to 36,000 containers per hour. FLC Extremely flexible and reliable, meeting the highest technical standards with an excellent price/benefit ratio. With the FLC line, Bosch has expanded its product portfolio in the medium output range. The continuous motion machine provides a processing range with filling volumes of 0.5 - 500 ml. A "V-cleat" conveyor system offers advantages in ease of size changeover. An innovative control system provides ease of use, high reliability and reproducible production settings. FLM 4080 The filling and sealing machines of the FLM series are developed to fill and close injection and infusion bottles. They stand out by their innovative design with a vertical machine plate. The wide processing range of up to 500 ml and the high output of up to 36,000 containers per hour mark the flexibility of the machine. FLP The filling and sealing machines FLP are ideal for filling and sealing injection and infusion bottles as well as threaded bottles and bottles for drop-applicators. The continuous method of operation must be emphasized just as much as the linear transportation system. MLF The MLF 3002 IN is ideal for filling and sealing injection bottles, whilst the MLF 3002 TR is used for filling and sealing infusion, threaded and plastic bottles as well as bottles with drop-applicator. MRF Filling and sealing machines in the MRF series are ideal for filling and sealing injection, infusion, screw neck and plastic bottles. The short delivery times are worth mentioning. These are only 3 months for the standard modular system. Filling and Sealing Machines for Pre-filled Syringes and Cartridges A wide range of profitable features make installations for filling and sealing prefilled syringes and cartridges attractive. Bosch incorporates, for instance, a prism-clip system for container transportation in these installations. FLS The FLS is a trendsetter, conceived with leading edge technology- specifically for the growing market of disposable syringes. Along with advanced technology, flexibility, configurability and short delivery time, the FLS offers an excellent cost-performance ratio. During the development of the FLS, the 3D models were run on a 3D design simulator. This included all of the new innovative design aspects that were specifically designed for the FLS. Since nearly all possible combinations and variations were simulated on the computer before machine production, measurable customer benefits are maximized while risks and delivery times are minimized. MLD The flexible multi-function machine MLD is used to process ready-to-use syringes and cartridges. Its wide processing spectrum ranges from dental or insulin cartridges right up to contrast medium cartridges. Sealing Machines for Injection and Infusion Bottles GMP-compliant construction or fast and easy size changeover: attributes that make Bosch sealing machines for injection and infusion bottles stand out. A range of extra equipment can also be delivered for these installations. VRK VRK for aluminum overseal capping of injection and infusion bottles VRK S for applying screw caps onto threaded bottles and bottles for drop-applicators VRK A for pressing-on. VRT The sealing machines VRT are ideal for sealing (overseal capping) injection and infusion bottles.
Machines by Type
We possess extraordinary pharmaceutical expertise with over 10,000 installations installed around the world for the pharmaceutical liquids sector and as the world leader in sterile applications. We deliver our machines not only in compliance with the relevant international standards, but our documentation, qualification and validation can also help you to start production with your new installations much faster and much more easily.
On these machines, containers are fed individually and considerately through several stations: flooding, washing (with or without ultrasonic support), blowing out and transfer to a downstream sterilising tunnel.
RQU and RQN
The washing machines RQU and RQN are ideal for washing ampoules. The installations outstanding due to their optimum accessibility, for instance, and are very easy to operate.
RQU DZ and RQN DZ
The washing machines RQU DZ and RQN DZ are ideal for washing injection and infusion bottles. The installations operate with a maximum of 10 stations for inner washing and 5 stations for outer washing of containers.
RRU and RRN
The RRU and RRN washing machines are ideal for washing injection bottles, infusion bottles, ampoules, cartridges and syringes. They are outstanding due to their optimum accessibility, for instance, and are very easy to operate.
HQL
HQL installations are ideal for sterilisation and depyprogenation of injection bottles, infusion bottles, ampoules, cartridges and ready-to-use syringes. This model is impressive due to a short dwell time in the tunnel which is the result of the hot air laminar flow process with its high degree of efficiency.
Bosch relies upon modern technologies in filling and sealing machines for ampoules. Thus these installations use, for instance, time/pressure filling systems for charging and laser technology for sealing.
ALF
The ALF model is ideal for filling and sealing ampoules, burn-open ampoules or injection bottles (in the combination version). The narrow design (800 mm width) ensures that operation is optimum. The machine is prepared for delivery together with an Isolator.
When it comes to filling and sealing screw neck bottles the best solution is to use Bosch filling and sealing machines. Their outstanding features include, for instance, GMP-compliant design, slim construction and delivery for a wide output range, up to 36,000 containers per hour.
FLC
Extremely flexible and reliable, meeting the highest technical standards with an excellent price/benefit ratio. With the FLC line, Bosch has expanded its product portfolio in the medium output range. The continuous motion machine provides a processing range with filling volumes of 0.5 - 500 ml. A "V-cleat" conveyor system offers advantages in ease of size changeover. An innovative control system provides ease of use, high reliability and reproducible production settings.
FLM 4080
The filling and sealing machines of the FLM series are developed to fill and close injection and infusion bottles. They stand out by their innovative design with a vertical machine plate. The wide processing range of up to 500 ml and the high output of up to 36,000 containers per hour mark the flexibility of the machine.
FLP
The filling and sealing machines FLP are ideal for filling and sealing injection and infusion bottles as well as threaded bottles and bottles for drop-applicators. The continuous method of operation must be emphasized just as much as the linear transportation system.
MLF
The MLF 3002 IN is ideal for filling and sealing injection bottles, whilst the MLF 3002 TR is used for filling and sealing infusion, threaded and plastic bottles as well as bottles with drop-applicator.
MRF
Filling and sealing machines in the MRF series are ideal for filling and sealing injection, infusion, screw neck and plastic bottles. The short delivery times are worth mentioning. These are only 3 months for the standard modular system.
A wide range of profitable features make installations for filling and sealing prefilled syringes and cartridges attractive. Bosch incorporates, for instance, a prism-clip system for container transportation in these installations.
FLS
The FLS is a trendsetter, conceived with leading edge technology- specifically for the growing market of disposable syringes. Along with advanced technology, flexibility, configurability and short delivery time, the FLS offers an excellent cost-performance ratio. During the development of the FLS, the 3D models were run on a 3D design simulator. This included all of the new innovative design aspects that were specifically designed for the FLS. Since nearly all possible combinations and variations were simulated on the computer before machine production, measurable customer benefits are maximized while risks and delivery times are minimized.
MLD
The flexible multi-function machine MLD is used to process ready-to-use syringes and cartridges. Its wide processing spectrum ranges from dental or insulin cartridges right up to contrast medium cartridges.
GMP-compliant construction or fast and easy size changeover: attributes that make Bosch sealing machines for injection and infusion bottles stand out. A range of extra equipment can also be delivered for these installations.
VRK
VRK for aluminum overseal capping of injection and infusion bottles VRK S for applying screw caps onto threaded bottles and bottles for drop-applicators VRK A for pressing-on.
VRT
The sealing machines VRT are ideal for sealing (overseal capping) injection and infusion bottles.
Colour Ring Coding and Labeling Machines
Isolator Technology Isolator technology is the smallest, most dependable and economical solution for a sterile room. Minimization of the sterile room is achieved because the machine no longer stands in the sterile room, but a sterile chamber is built over the machine. Besides the great economical advantages, this logical step brings about a degree of product reliability which has not been attained to date. Barrier systems are becoming increasingly important to the pharmaceutical industry. The improvement in product quality, the reduction of operating costs and the capability of longer production runs are significant advantages in comparison to conventional clean room production. The closed, aseptic work area in the isolator protects the drug against contamination by the operator. When highly potent compounds are processed the operator is also protected against contamination by the product. Bosch has shown its leading position with the largest market share in isolator lines for filling of parenterals. You can profit from this experience today. Bosch barrier systems - with integrated bio decontamination system Bosch Safe VAP - are available for all types of machines processing ampoules, vials, cartridges and ready-to-use syringes. MAFS- Mini Aseptic Filling Machine The MAFS is a high-performance filling and sealing system, complete with Isolator technology, made by Bosch TL-Systems (USA). A vertically positioned base plate separates the drive section from the aseptic work range. All drive components, pumps and lines as well as the entire electrical system are located outside of the sterile zone. Therefore they are freely accessible for changeovers, maintenance and repair work without breaking sterility. The very narrow sterile zone is easily accessible from the front and can be effectively wet cleaned. Colour Ring Coding Machines DRN The machine is ideal for colour ring coding on ampoules. It offers a total of 1296 different, electronically readable colour codings. Additionally, the DRN model yields good results by the fast change of the colour ring combination and by the plug-in ink unit. Labeling Machines When there is a requirement to guarantee a continuous method of operation for labeling ampoules or injection bottles, then Bosch installations are in demand. Bosch sets the standard when it comes to labeling machines, with their easy-to-operate and well-organised construction. ERS ERS machines are ideal for labeling ampoules and injection bottles. One of their features is a size-dependent microprocessor controller for label feed. Inspection Machines- Checkweighers For inspection of ampoules or infusion bottles Bosch relies upon installations that use many stations to inspect these items for seal integrity and other faults. Value here is placed upon ease of machine operation by using a touch screen and upon a validatable inspection process. KLD The crack detection machine KLD is an automatic machine for inspecting the seal integrity of ampoules, injection and infusion bottles as well as cartridges. It has 4 inspection stations that use high-voltage technology. Containers are inspected at 4 different points for overall height. Traying off Machines GLT The GLT machine is very suitable for traying off stable injection bottles. It can be used for attachment to a take-off conveyor on an upstream machine or as a stand-alone machine. Full area utilisation of containers in the magazine due to line offset must be emphasised.
Isolator technology is the smallest, most dependable and economical solution for a sterile room. Minimization of the sterile room is achieved because the machine no longer stands in the sterile room, but a sterile chamber is built over the machine. Besides the great economical advantages, this logical step brings about a degree of product reliability which has not been attained to date.
Barrier systems are becoming increasingly important to the pharmaceutical industry. The improvement in product quality, the reduction of operating costs and the capability of longer production runs are significant advantages in comparison to conventional clean room production. The closed, aseptic work area in the isolator protects the drug against contamination by the operator. When highly potent compounds are processed the operator is also protected against contamination by the product. Bosch has shown its leading position with the largest market share in isolator lines for filling of parenterals. You can profit from this experience today. Bosch barrier systems - with integrated bio decontamination system Bosch Safe VAP - are available for all types of machines processing ampoules, vials, cartridges and ready-to-use syringes.
MAFS- Mini Aseptic Filling Machine
The MAFS is a high-performance filling and sealing system, complete with Isolator technology, made by Bosch TL-Systems (USA). A vertically positioned base plate separates the drive section from the aseptic work range. All drive components, pumps and lines as well as the entire electrical system are located outside of the sterile zone. Therefore they are freely accessible for changeovers, maintenance and repair work without breaking sterility. The very narrow sterile zone is easily accessible from the front and can be effectively wet cleaned.
DRN
The machine is ideal for colour ring coding on ampoules. It offers a total of 1296 different, electronically readable colour codings. Additionally, the DRN model yields good results by the fast change of the colour ring combination and by the plug-in ink unit.
When there is a requirement to guarantee a continuous method of operation for labeling ampoules or injection bottles, then Bosch installations are in demand. Bosch sets the standard when it comes to labeling machines, with their easy-to-operate and well-organised construction.
ERS
ERS machines are ideal for labeling ampoules and injection bottles. One of their features is a size-dependent microprocessor controller for label feed.
For inspection of ampoules or infusion bottles Bosch relies upon installations that use many stations to inspect these items for seal integrity and other faults. Value here is placed upon ease of machine operation by using a touch screen and upon a validatable inspection process.
KLD
The crack detection machine KLD is an automatic machine for inspecting the seal integrity of ampoules, injection and infusion bottles as well as cartridges. It has 4 inspection stations that use high-voltage technology. Containers are inspected at 4 different points for overall height.
GLT
The GLT machine is very suitable for traying off stable injection bottles. It can be used for attachment to a take-off conveyor on an upstream machine or as a stand-alone machine. Full area utilisation of containers in the magazine due to line offset must be emphasised.
Packaging Machines for Dry Foods
Package Makers PKD The PKD package maker offers highly developed above-average dependability and operating-control standards. PKR PKR package makers can be designed to meet individual requirements: for single or double bag or for inner-bag outer-carton packs. PKS The PKS series offers great flexibility through the combination of the bag form and fill section, the pocket chain and the closing section of package makers. PMC By utilizing the state-of-the-art servo technology and electronics Bosch has developed a packaging machine that sets new standards: maximum possible flexibility and utmost technical standard for customer-oriented requirements - and this at a fair market price. PMC Neutravac With this machine, catchwords such as size flexibility, degree of efficiency and availability, excellent pack appearance and extremely high requirements of product protection become a reality for your production. PME The machine can be configured to meet the needs of various applications and industries. The flexible machine concept allows for pack sizes, top closures and materials to be changed within a short time. The PME provides the possibility of packaging a broad range of products securely, efficiently and to a superior degree of quality. Fragile products or products that are difficult to fill through the forming tube can be dosed from above the package transport directly into the previously formed pack. Multi Bag Packers Bosch multiple unit packers are flexible and work economically and reliably as well as being easy to operate in different size and output ranges - both for carton as well as kraft paper multipacks. GSA The GSA multi-bag packers allow cost-advantageous kraft papers to be used, regardless of whether they are printed or unprinted. In this way, your products are always effectively protected en route to the customer and they can be manufactured in pallet and stackable containers. GSH 5031 B Its numerous technical and economical features make the GSH multi-bag packer outstanding. These include the machine's state-of-the-art technical standard and high performance just as much as the fact that operations can be carried out very economically with the GSH. Checkweighers KWE Bosch electronic checkweighers in the extensive Bosch checkweigher module program are equipped with microprocessor control systems and are ideal for universal applications. Cartoner Bosch cartoners are particularly suitable for bag-in-box applications. CBK 4090/4100/4150 The proven machines in the CBK series are especially ideal for large sizes and thus offer many variants and options typical for different foodstuffs. CBT The CBT-series has proven its reliability in many dozens of applications. A great number of installed applications guarantees highest dependability and offers a wide variety of applications and infeed systems. CUC Featuring various innovations and a wide size range the CUC is just the right machine for many applications in the food industry. CUK 3070 The CUK is just the right machine for many applications in the foodstuffs industry machine with its wide size range and many proven optional extras and variants for custom-made applications. CUT The CUT 120 cartoning machines can be used both as a stand-alone machine with different product feeds as well as bag-in-box together with a Bosch bag form fill and seal machine. The large size range allows you versatile and flexible employment. Bag Form Fill and Seal Machines Bosch bag form fill and seal machines can be used to pack different products in the food, confectionery and chemo-technical sectors. Ideal for the widest range of bag shapes such as pillow bags, gusseted bags, stand-up bags and bags with corner sealing and Trans-Zip reclosure and much more. SVE 2510 AR The sensational engineering and the usual high Bosch quality makes the SVE 2510 AR the entry-level machine in the high-performance class for everyone. SVE 2510 QR The SVE 2510 QR makes it possible without additional machine height to produce corner sealed stand-up bags. The product breakage is minimized. The corner seal width is adjustable and due to offset long seam optimal use for printing at the front and rear panels. SVE 2510 DR Continuous bag form fill and seal machine for producing Doy style stand - up pouches (SUP) and more. Astonishing versatility at incredible speeds at low machine height. SVE 2510 AM The eye-catching mini-triangle bags are easy and fast produced by the SVE 2510 AM. Qualified for packing confectionery, instant powder drinks, nuts etc. SVE 1800 MR One weigher and one machine for the same output as two separate weighers and two baggers. SVE 3600 LR On the SVE 3600 LR you can produce a multiplicity of packing forms on a flexible way, fast and simply. SVE 3600 WR The SVE 3600 WR with its unique Q-technology is the fastest vertical form, fill and seal machine. Continuous bag form fill and seal machine for producing corner sealed bags up to 360mm level. SVK 3600 P Just as with all machines in the SVK series, the Bosch SVK 3600 P provides maximum flexibility in size range and with bag styles. Furthermore, it is able to manufacture bags fitted with an integral Trans-Zip reclosure. Terra 25 The Bosch Terra 25 is the cost-advantageous alternative in the bag form fill and seal machine sector for your production. It is designed for the medium output range, provides you with excellent results and therefore comprises the cost-advantageous entry level solution. SVK 2500 P Just as with all machines in the SVK series, the Bosch SVK 2500 P provides maximum flexibility in size range and with bag styles. Furthermore, it is able to manufacture bags fitted with an integral Trans-Zip reclosure. SVB 2501 A The property of being able to operate at high cycles makes the SVB 2501 A the economic solution for your production of bags. SVB 3601 L The SVB 3601 L provides the opportunity to manufacture bags quickly and economically. The SVB 3601 L was designed to manufacture large bags. SVB 3601 Q The SVB 3601 Q, just as with all SVB machine models, guarantees flexibility and economy. The machine is also able to manufacture bags that have a corner seal. SVB 3601 R The SVB 3601 R offers a substantial number of production variants to our customers. The machine is able to produce bags with corner seals and Trans-Zip reclosure. SVZ 1200 A The SVZ 1200 A gripper draw-off machine is the economic alternative for many branches.
PKD
The PKD package maker offers highly developed above-average dependability and operating-control standards.
PKR
PKR package makers can be designed to meet individual requirements: for single or double bag or for inner-bag outer-carton packs.
PKS
The PKS series offers great flexibility through the combination of the bag form and fill section, the pocket chain and the closing section of package makers.
PMC
By utilizing the state-of-the-art servo technology and electronics Bosch has developed a packaging machine that sets new standards: maximum possible flexibility and utmost technical standard for customer-oriented requirements - and this at a fair market price.
PMC Neutravac
With this machine, catchwords such as size flexibility, degree of efficiency and availability, excellent pack appearance and extremely high requirements of product protection become a reality for your production.
PME
The machine can be configured to meet the needs of various applications and industries. The flexible machine concept allows for pack sizes, top closures and materials to be changed within a short time. The PME provides the possibility of packaging a broad range of products securely, efficiently and to a superior degree of quality. Fragile products or products that are difficult to fill through the forming tube can be dosed from above the package transport directly into the previously formed pack.
Bosch multiple unit packers are flexible and work economically and reliably as well as being easy to operate in different size and output ranges - both for carton as well as kraft paper multipacks.
GSA
The GSA multi-bag packers allow cost-advantageous kraft papers to be used, regardless of whether they are printed or unprinted. In this way, your products are always effectively protected en route to the customer and they can be manufactured in pallet and stackable containers.
GSH 5031 B
Its numerous technical and economical features make the GSH multi-bag packer outstanding. These include the machine's state-of-the-art technical standard and high performance just as much as the fact that operations can be carried out very economically with the GSH.
Bosch cartoners are particularly suitable for bag-in-box applications.
CBK 4090/4100/4150
The proven machines in the CBK series are especially ideal for large sizes and thus offer many variants and options typical for different foodstuffs.
CBT
The CBT-series has proven its reliability in many dozens of applications. A great number of installed applications guarantees highest dependability and offers a wide variety of applications and infeed systems.
CUC
Featuring various innovations and a wide size range the CUC is just the right machine for many applications in the food industry.
CUK 3070
The CUK is just the right machine for many applications in the foodstuffs industry machine with its wide size range and many proven optional extras and variants for custom-made applications.
CUT
The CUT 120 cartoning machines can be used both as a stand-alone machine with different product feeds as well as bag-in-box together with a Bosch bag form fill and seal machine. The large size range allows you versatile and flexible employment.
Bosch bag form fill and seal machines can be used to pack different products in the food, confectionery and chemo-technical sectors. Ideal for the widest range of bag shapes such as pillow bags, gusseted bags, stand-up bags and bags with corner sealing and Trans-Zip reclosure and much more.
SVE 2510 AR
The sensational engineering and the usual high Bosch quality makes the SVE 2510 AR the entry-level machine in the high-performance class for everyone.
SVE 2510 QR
The SVE 2510 QR makes it possible without additional machine height to produce corner sealed stand-up bags. The product breakage is minimized. The corner seal width is adjustable and due to offset long seam optimal use for printing at the front and rear panels.
SVE 2510 DR
Continuous bag form fill and seal machine for producing Doy style stand - up pouches (SUP) and more. Astonishing versatility at incredible speeds at low machine height. SVE 2510 AM
The eye-catching mini-triangle bags are easy and fast produced by the SVE 2510 AM. Qualified for packing confectionery, instant powder drinks, nuts etc.
SVE 1800 MR
One weigher and one machine for the same output as two separate weighers and two baggers.
SVE 3600 LR
On the SVE 3600 LR you can produce a multiplicity of packing forms on a flexible way, fast and simply.
SVE 3600 WR
The SVE 3600 WR with its unique Q-technology is the fastest vertical form, fill and seal machine. Continuous bag form fill and seal machine for producing corner sealed bags up to 360mm level.
SVK 3600 P
Just as with all machines in the SVK series, the Bosch SVK 3600 P provides maximum flexibility in size range and with bag styles. Furthermore, it is able to manufacture bags fitted with an integral Trans-Zip reclosure.
Terra 25
The Bosch Terra 25 is the cost-advantageous alternative in the bag form fill and seal machine sector for your production. It is designed for the medium output range, provides you with excellent results and therefore comprises the cost-advantageous entry level solution.
SVK 2500 P
Just as with all machines in the SVK series, the Bosch SVK 2500 P provides maximum flexibility in size range and with bag styles. Furthermore, it is able to manufacture bags fitted with an integral Trans-Zip reclosure.
SVB 2501 A
The property of being able to operate at high cycles makes the SVB 2501 A the economic solution for your production of bags.
SVB 3601 L
The SVB 3601 L provides the opportunity to manufacture bags quickly and economically. The SVB 3601 L was designed to manufacture large bags.
SVB 3601 Q
The SVB 3601 Q, just as with all SVB machine models, guarantees flexibility and economy. The machine is also able to manufacture bags that have a corner seal.
SVB 3601 R
The SVB 3601 R offers a substantial number of production variants to our customers. The machine is able to produce bags with corner seals and Trans-Zip reclosure.
SVZ 1200 A
The SVZ 1200 A gripper draw-off machine is the economic alternative for many branches.
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