We possess extraordinary pharmaceutical expertise with over 10,000 installations installed around the world for the pharmaceutical liquids sector and as the world leader in sterile applications. We deliver our machines and installations not only in compliance with the relevant international standards, but our documentation, qualification and validation can also help you to start production with your new installations much faster and much more easily.
MACHINES
Ampoules / Ampoules and Injection Bottles
The manufacturing process for ampoules or combined processing of ampoules and injection bottles typically begins with a compact system. Ampoule compact systems are finished using sterile room equipment (on-site sterile room) or with the innovative isolator technology (machine sterile room). The containers are checked, labelled and end-packaged on subsequent machines. Bosch provides an individually configurable range of machinery for these applications for maximum production capacities of up to 27,000 ampoules per hour.
Processing Steps
- Cleaning
- Sterilisation
- Filling and sealing
- Colour ring marking
Subsequent Processing Steps
- Check for particle freedom and cosmetic defects
- Check ampoules for impermeability with the inspection machine KLD
- Application of a self-adhesive label with the labeling machine ERS
- End packing of ampoules in thermoformed blisters, folding boxes and/or cartons with cartoning machines.
Injection and Infusion Bottles
The manufacturing process for injection bottles typically begins with a compact system. This consists of a washing machine, a drying and sterilising tunnel, a filling and sealing machine, an overseal capping machine as well as a system for traying-off. Compact systems for injection bottles are finished using sterile room equipment (on-site sterile room) or in the innovative isolator technology (machine sterile room). The containers are checked, labelled and end-packaged on subsequent machines. Bosch provides an individually configurable range of machinery for this application for maximum production capacities of up to 36,000 containers per hour.
Processing Steps
- Cleaning
- Sterilisation
- Filling and pressing in stoppers
- Oversealing
- Traying off
Subsequent Processing Steps
- Check for particle freedom and cosmetic defects
- Check injection bottles for impermeability with the inspection machine KLD
- Application of a self-adhesive label with the labeling machine ERS
- End packing of containers in thermoformed blisters, folding boxes and/or cartons with cartoning machines
Screw Neck Bottles
The manufacturing process for these types of containers is carried out by a line that typically has the following elements: washing machines, drying and sterilising tunnel, fill and seal machine as well as traying machinery. The containers are checked, labelled and end-packaged on subsequent machines. The Bosch individually configurable range of machinery includes plants for maximum production capacities of up to 24,000 containers per hour.
Processing Steps
- Cleaning
- Sterilisation
- Filling and pressing in stoppers
- Oversealing
- Traying off
Subsequent Processing Steps:
- Check for particle freedom and cosmetic defects
- Check containers for impermeability with the inspection machine KLD
- Application of a self-adhesive label with the labeling machine ERS
- End packaging of containers into folding cartons with cartoning machines
Cartridges
The manufacturing process for cartridges bottles typically begins with a compact system. This consists of a washing machine, a drying and sterilising tunnel, a filling and sealing machine, an overseal capping machine as well as a system for traying-off the cartridges. Compact systems for cartridges are finished using sterile room equipment (on-site sterile room) or in the innovative isolator technology (machine sterile room).The containers are checked, labelled and end-packaged on subsequent machines. Bosch provides an individually configurable range of machinery for this application for maximum production capacities of up to 36,000 cartridges per hour.
Processing Steps
- Cleaning
- Sterilisation
- Filling and pressing in stoppers
Subsequent Processing Steps
- Check for particle freedom and cosmetic defects (also possible inline)
- Application of a self-adhesive label on the labeling machine ERS
- End packing of cartridges in thermoformed blisters, folding boxes and/or cartons with cartoning machines
Syringes
The manufacturing process for injection bottles typically begins with a syringe compact system. This consists of a washing machine, a drying and sterilising tunnel, a filling and sealing machine, an overseal capping machine as well as a system for placing the syringes in trays. These compact systems are finished using sterile room equipment (on-site sterile room) or with the innovative isolator technology (machine sterile room). Bosch provides an individually configurable range of machinery for this application for maximum production capacities of up to 18,000 syringes per hour.
Processing Steps
- Removal from trays
- Cleaning
- Sterilisation
- Filling and assembling
- Insertion in trays
Further Processing
- Inspection for particle freedom and cosmetic defects (also possible inline before insertion into trays)
- Application of a self-adhesive label with the labeling machine ERS
Needle-Free Injections
Bosch also offers and individually configurable range of machinery for processing needle-free injections.
